Dexamethason acetate

CAS No. 1177-87-3

Dexamethason acetate( NSC 39471 )

Catalog No. M10604 CAS No. 1177-87-3

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 41 In Stock
1G 69 In Stock

Biological Information

  • Product Name
    Dexamethason acetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.
  • Description
    Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.(In Vitro):protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response.Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release. (In Vivo):It has previously been reported that treatment with Dexamethasone (Hexadecadrol) at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water).Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC 39471
  • Pathway
    Endocrinology/Hormones
  • Target
    Annexin A
  • Recptor
    Annexin A1| Glucocorticoid Receptor| IL receptor| iNOS
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1177-87-3
  • Formula Weight
    434.51
  • Molecular Formula
    C24H31FO6
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 20 mg/mL (46.02 mM); DMSO: 87 mg/mL (200.23 mM)
  • SMILES
    O=C1C=C[C@@]2(C)C(CC[C@@H]3[C@]2(F)[C@@H](O)C[C@@]4(C)[C@H]3C[C@@H](C)[C@]4(O)C(COC(C)=O)=O)=C1
  • Chemical Name
    2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Funato H, et al. Brain Res. 2006 Oct 30;1117(1):125-34.
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