
Dexamethason acetate
CAS No. 1177-87-3
Dexamethason acetate( NSC 39471 )
Catalog No. M10604 CAS No. 1177-87-3
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 41 | In Stock |
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1G | 69 | In Stock |
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Biological Information
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Product NameDexamethason acetate
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NoteResearch use only, not for human use.
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Brief DescriptionDexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.
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DescriptionDexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.(In Vitro):protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response.Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release. (In Vivo):It has previously been reported that treatment with Dexamethasone (Hexadecadrol) at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water).Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss.
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In Vitro——
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In Vivo——
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SynonymsNSC 39471
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PathwayEndocrinology/Hormones
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TargetAnnexin A
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RecptorAnnexin A1| Glucocorticoid Receptor| IL receptor| iNOS
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1177-87-3
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Formula Weight434.51
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Molecular FormulaC24H31FO6
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL (46.02 mM); DMSO: 87 mg/mL (200.23 mM)
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SMILESO=C1C=C[C@@]2(C)C(CC[C@@H]3[C@]2(F)[C@@H](O)C[C@@]4(C)[C@H]3C[C@@H](C)[C@]4(O)C(COC(C)=O)=O)=C1
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Chemical Name2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Funato H, et al. Brain Res. 2006 Oct 30;1117(1):125-34.
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